MersV1, Main, Exploration, bibRecord, 001F45

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Identifieur interne : 001F45 ( Main/Exploration ); précédent : 001F44; suivant : 001F46

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Auteurs : Daniela Niemeyer [Allemagne] ; Thomas Zillinger ; Doreen Muth ; Florian Zielecki ; Gabor Horvath ; Tasnim Suliman ; Winfried Barchet ; Friedemann Weber ; Christian Drosten ; Marcel A. Müller

Source :

Journal of virology [ 1098-5514 ] ; 2013.

RBID : pubmed:24027320

Descripteurs français

KwdFr :
- ARN double brin (métabolisme), Coronavirus (croissance et développement), Coronavirus (pathogénicité), Données de séquences moléculaires, Humains, Immunité innée (immunologie), Infections à coronavirus (immunologie), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Interféron de type I (antagonistes et inhibiteurs), Moyen Orient, Protéines virales régulatrices ou accessoires (métabolisme), Similitude de séquences d'acides aminés, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés.
MESH :
- antagonistes et inhibiteurs : Interféron de type I.
- croissance et développement : Coronavirus.
- immunologie : Immunité innée, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- métabolisme : ARN double brin, Infections à coronavirus, Protéines virales régulatrices ou accessoires, Syndrome respiratoire aigu sévère.
- pathogénicité : Coronavirus.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Données de séquences moléculaires, Humains, Moyen Orient, Similitude de séquences d'acides aminés, Séquence d'acides aminés.

English descriptors

KwdEn :
- Amino Acid Sequence, Coronavirus (growth & development), Coronavirus (pathogenicity), Coronavirus Infections (immunology), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Humans, Immunity, Innate (immunology), Interferon Type I (antagonists & inhibitors), Middle East, Molecular Sequence Data, RNA, Double-Stranded (metabolism), Sequence Homology, Amino Acid, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Viral Regulatory and Accessory Proteins (metabolism).
MESH :
- chemical , antagonists & inhibitors : Interferon Type I.
- chemical , metabolism : RNA, Double-Stranded, Viral Regulatory and Accessory Proteins.
- geographic : Middle East.
- growth & development : Coronavirus.
- immunology : Coronavirus Infections, Immunity, Innate, Severe Acute Respiratory Syndrome.
- metabolism : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- pathogenicity : Coronavirus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Humans, Molecular Sequence Data, Sequence Homology, Amino Acid.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.

DOI: 10.1128/JVI.01845-13
PubMed: 24027320

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA. </div>
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Serveur d'exploration MERS

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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